I used a 1980 280SE as a daily driver for about 15 years, adding 350 000km to its odometer in that time. Performance was more than OK at coastal altitude, but in Johannesburg (1600m elevation), its a little strained. Handling is nice and crisp with the lower engine weight. My pick of the 116 family for daily driver duty would be a 450SE. The engine is still light enough for handling to be OK, and performance is useful. I have also used by AMG6.9 as a daily for a couple of years, and the fuel consumption is punitive, even with new injectors, timing chain, everything properly set up. Performance is vicious, but really a bit more than needed. And its a handful in the tight and twisty stuff due to the massive engine weight.
Not sure where you're from, but my cars are all euro spec, so the 280 has 185hp. THe US spec 280 has a LOT less power, which I would think would make it a bit too lethargic for modern traffic.
My 280SE is now on 565 000km IIRC, and I'm getting started on a full rebuild. The intent is to return it to daily driver duty after the rebuild.